"The Night Shift" focuses on the men and women who work the overnight shift at San Antonio Memorial Hospital. They are an irreverent and special breed, particularly adrenaline junkie T.C. Callahan. After three grueling tours of duty in Afghanistan, T.C. is about to learn that his toughest battles will be fought right here at home. He and his team of late-night docs, including best friend Topher and protégé Drew, know how to let off steam with the casual prank or two, but when lives are at stake, they are all business. Unfortunately, the night shift is now under new senior management and boss Michael Ragosa, who has to balance the real-world pressures of cutting costs while battling the stigma that he is more interested in saving money than helping people. A shooting at a nearby college sends TC, Jordan, Drew and Amira into the field, where they assist Rick with a deadly situation. Scott implements a new training program and locks horns with Julian. Drew struggles with frustrations about going to Army Ranger School while Shannon and TC both contemplate their future at San Antonio Memorial. TC and Jordan accompany a SWAT team on a raid and wind up with an emergency room full of sickened immigrants, including one with murderous intentions. Scott pulls a dream team together to impress the Colonel in charge of setting up a combat training program. More is learned about Cain's past. Kenny shares some big news with the group, while Shannon keeps something personal from Paul. When Jordan realizes the hospital is under cyber-attack, she leads the team in managing patient care as chaos ensues. Drew and Kenny treat a critical patient forcing Drew to call on his medical and military training. TC joins Rick and his partner on a SWAT drug raid. Meanwhile, he wrestles with whether or not he should return to Syria to tie up loose ends. When protestors descend on a funeral for a dear member of the night shift family, multiple veterans are injured and brought to San Antonio Memorial for treatment. A high profile politician from Drew's past triggers flashbacks to his time in Iraq. Jordan, Scott, and TC disagree on how to best provide care for the politician. Paul and Shannon must improvise while tending to Doug, a former POW. Cain and Drew treat a fearless photographer. Kenny joins Drew at his MMA veteran's support group and finds himself in the fight of his life. Jordan and Cain treat casualties from a hotel fire while Shannon follows a hunch to help save a young victim. Paul's superstar sister, Dr. Bella Cummings, pays a visit to San Antonio Memorial and provides desperately needed support during a busy shift. Meanwhile, TC finally returns home, forcing him to deal with Topher's death.