In the year 2048 the police have a new tool in their arsenal- Synthetics, robots who are tasked with assuring the safety of the humans who created them. Not everyone is pleased with the changes. Detective John Kennex, who has been wounded in action, returns to the force and learns that his new partner is a Synthetic named Dorian. Dorian's programming is very different than that of the normal Synthetic, with a capability to experience emotions making him seem almost human, but John still mistrusts the machine at his side. Can they work together as a team? Det. Kennex and Dorian investigate a string of murders by a copycat of a serial killer whom Kennex’s father put in jail. As the investigation unfolds, biotechnology from the future sheds light on crimes of the past. Meanwhile, Dorian receives his performance evaluation since being reactivated. When Det. Kennex and Dorian investigate the murder of a "chrome," there are no signs of trauma, other than a very small pinprick on the back of his neck. As the investigation unfolds, it’s revealed that the murder suspect is tapping into the DNA of his victims in pursuit of perfection. A deadly crime from the future occurs when a "smart home" goes terribly bad and turns on its occupants. Detective Kennex and Dorian lead the investigation that forces them to interface with a house that is represented by a mysterious hologram character. When Det. Kennex and Dorian investigate the simultaneous and sudden deaths of two genetically-enhanced - or "chrome" - children, a fatal dose of the perfect designer drug appears to be the cause. As the investigation unfolds and a recent drowning victim is mysteriously connected, the case takes an unexpected turn. Meanwhile, Kennex endures painful flashes from the past and pays a visit to the recollectionist. There are consequences and casualties when Danica, an advanced DRN that operates more like a soldier than a cop, is rebuilt and on a rampage. With few clues about her mission, location and innocent lives being lost, Kennex and Dorian look to Nigel, a genius roboticist and DRN creator, in attempt to track her down.